Vm24, a natural immunosuppressant peptide potently and selectively blocks Kv1.3 potassium channels of human T cells
نویسندگان
چکیده
Department of Biophysics and Cell Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary, 4032: Z.V., F.P, R.G., G.P Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Cuernavaca, Mexico 62210: G.G-B, G.P-A, Y.R., L.D.P. Ecologie, Systématique et Evolution, Université Paris-Sud, F-91405, Orsay cedex, France; UMR 8079, CNRS, F-91405, Orsay cedex, France: R.C.R.V. Departamento de Biología Molecular de Plantas, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Cuernavaca, Mexico 62210: L.C. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030: R.B.T, C.B. Molecular Pharmacology Fast Forward. Published on May 23, 2012 as doi:10.1124/mol.112.078006
منابع مشابه
Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.
Blockade of Kv1.3 K(+) channels in T cells is a promising therapeutic approach for the treatment of autoimmune diseases such as multiple sclerosis and type 1 diabetes mellitus. Vm24 (α-KTx 23.1) is a novel 36-residue Kv1.3-specific peptide isolated from the venom of the scorpion Vaejovis mexicanus smithi. Vm24 inhibits Kv1.3 channels of human lymphocytes with high affinity (K(d) = 2.9 pM) and e...
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